盖宏伟 Professor Hongwei Gai

发布时间:2014-12-03  访问次数:7489

  

Dr. Hongwei Gai is a professor of School of Chemistry and Materials Science at Jiangsu Normal University since Dec. 2011. He earned his doctorate degree in analytical chemistry at Chinese Science of Academy, Dalian Institute of Chemical Physics in 2005. After he did his postdoctoral work in Health Science Center at Texas University in San Antonio, Dr. Gai joined Biomedical Engineering Center at Hunan University as an appointed professor in Dec. 2006. Dr. Gai became a full professor in Aug. 2009 and then in School of Biology after Jan. 2010.  Dr. Gai’s research focuses on single molecule fluorescence imaging and the application in chemistry and biology. Dr. Gai has published over 30 scientific papers most in the journals like Anal ChemLab ChipChem CommunAngew Chem Int Ed, and he holds five patents. Dr. Gai received Young Scholar and General Project from National Natural Science Foundation.


  

名:盖宏伟

学位学历:博士研究生

职称:教授

职务:副院长

学科专业:分析化学

E-mailgai@jsnu.edu.cn

个人简历

1.教育背景和工作简历

1993年9月- 1997年7月:西安交通大学,化工学院,学士

1997年9月- 2000年7月:大连理工大学,化工学院,硕士

2000年9月- 2005年11月:中国科学院大连化学物理研究所,分析化学,博士

2005年11月-2006年10月:美国德州大学圣安东尼奥健康科学中心,博士后

2006年10月-2011年11月:湖南大学生物医学工程中心/生物学院,校聘教授/教授

2011年12月至今:江苏师范大学,化学与材料科学学院,教授

2.工作成绩及学术成果。

已发表SCI收录学术论文三十余篇,多数发表于Anal Chem, Lab Chip, Chem Commun, Angew Chem Int Ed等国际著名刊物。申请发明专利十余项,已授权五项。主持国家自然科学基金面上项目2项、青年项目1项,江苏省高校自然科学研究重大项目1项湖南省科技厅项目2项,江苏省高校“青蓝工程”中青年学术带头人,江苏省第五期“333高层次人才培养工程”第三层次,江苏省“六大人才高峰”高层次人才。第十一届江苏省青年联合会委员。第九届徐州市云龙区政协委员。

【研究领域和兴趣】

主要从事单分子荧光检测研究。以显微成像为主要手段,在细胞和单分子层面上,开展以高灵敏检测和动态监测为特征的疾病早期诊断和致病机理研究,包括单分子单颗粒传感,动态单分子间相互作用的监测,纳米显微技术等。

【成绩及获奖情况】

1.2010年湖南省化学化工协会青年化学奖

2.2011年大连市科学技术奖励,二等奖

【承担的主要科研项目】

序号

项目名称

项目级别

项目来源

项目号

项目排序

起止日期

1

高分辨光流控显微成像技术及应用研究

国家

国家自然科学基金

21575053

1

2016.1-2019.12

2

单分子远场三维纳米成像技术

国家

国家自然科学基金

21075033

1

2011.1-2013.12

3

高量单分通子微阵列芯片

国家

国家自然科学基金

20705007

1

2008.1-2010.12

4

基于单分子微阵列芯片的肺癌骨髓微转移研究

省级

湖南省科技厅

2008WK3004

1

2008.12-2009.12

5

微芯片上的无透镜显微成像系统

省级

湖南省科技厅

2011TT2026     湘科条字【2011】128号

1

2012.1-2012.12

6

江苏省高校“青蓝工程”中青年学术带头人

省级

江苏省教育厅


1

2013.1-2015.12

7

江苏省高校自然科学研究重大项目

省级

江苏省教育厅

16KJA150006

1

2016.9-2019.12

8

江苏省“六大人才高峰”高层次人才

省级

江苏省人力资源和社会保障厅


1

2017.1-2018.12

9

江苏省第五期“333高层次人才培养工程”第三层次

省级

江苏省人才办


1

2017.1-2018.12

【代表性论文】

28, Suli Dong, Xiaojun Liu, Qingquan Zhang, Wenfeng Zhao, Chenghua Zong, Aiye Liang, Hongwei Gai *, Sensing active heparin by counting aggregated quantum dots at single-particle level, ACS Sensors, 2017, 2, 80-86.

27, Qiangquan Zhang, Hanlin Li, Xiaojun Liu, Wenfeng Zhao, Chenghua Zong, Hongwei Gai *, A self-driven miniaturized liquid fuel cell, Chemical Communications, 2016, 52, 12068-12071.

26, Qingquan Zhang, Meng Xu, Xiaojun Liu, Wenfeng Zhao, Chenghua Zong, Yang Yu, Qi Wang *, Hongwei Gai*, Fabrication of Janus droplets by evaporation driven liquid-liquid phase separation, Chemical Communications, 2016, 52, 5015-5018.

25, Xiaojun Liu, Zhangjian Wu, Qingquan Zhang, Wenfeng Zhao, Chenghua Zong, Hongwei Gai*, Single Gold Nanoparticle-Based Colorimetric Detection of Picomolar Mercury Ion with Dark-Field Microscopy, Analytical Chemistry, 2016, 88, 2119-2124.

24, Wenfeng Zhao*, Wei Jia, Mimi Sun, Xiaojun Liu, Qingquan Zhang, Chenghua Zong, Hongwei Gai*, Colorimetric detection of Cu 2+ by surface coordination complexes of polyethyleneimine-capped Au nanoparticles, Sensors and Actuators: B. Chemical, 2016, 223, 411-416.

23, Xiaojun Liu, Yawei Wang, Yang Tu, Ziqi Zhu, Xiaogang Li, Qingquan Zhang, Wenfeng Zhao, Yuling Li, Hongwei Gai*, A rapid and simple approach for glycoform analysis, Analytica Chimica Acta, 2015, 865,71-75.

22, Xingbo Shi, Suli Dong, Minmin Li, Xiaojun Liu, Qingquan Zhang, Wenfeng Zhao, Chenghua Zong, Yewang Zhang, Hongwei Gai*, Counting quantum dot aggregates for the detection of biotinylated proteins, Chemical Communications, 2015, 51, 2353-2356.

21, Xingbo Shi, Minmin Li, Wenfeng Zhao, Aiye Liang , Xiaojun Liu, Hongwei Gai*, Spectral imaging superlocalization microscopy for quantum dots, Sensors and Actuators: B. Chemical, 2015, 207, 308-312.

20, Wenfeng Zhao, Suli Dong, Lichun Sun, Qi Wang*, Hongwei Gai*, Investigating the Photostability of Quantum Dots at the Single-MoleculeLevel, Chemistry-An Asian Journal, 2014, 9, 3542-3548.

19, Qingquan Zhang, Xiaojun Liu, Dayu Liu, Hongwei Gai*, Ultra small droplet generation via volatile component evaporation, Lab on a Chip, 2014,14(8), 1395 - 1400.

18, Xiaojun Liu, Qingquan Zhang, Yang Tu,  Hongwei Gai*, Single Gold Nanoparticle Localized Surface Plasmon Resonance Spectral Imaging for Quantifying Binding Constant of Carbohydrate–Protein Interaction, Analytical Chemistry, 2013, 85, 11851–11857.

17,Xingbo Shi, Yang Tu, Xiaojun Liu, Edward S Yeung, Hongwei Gai*, Photobleaching of Quantum Dots by Non-resonant Light, Physical Chemistry Chemical Physics, 2013, 15, 3130-3132.

16,刘晓君,涂洋,盖宏伟*,单分子宽场光学显微成像技术,化学进展,201325370-379.

15,Xiaojun Liu, Hui Wang, Aiye Liang, Yuling Li, Hongwei Gai*, Bingcheng Lin*, Determination of binding constants between 1 one protein and multiple carbohydrates by affinity chromatography on a microchip, Journal of Chromatography A, 2012, 1270,340-343.  

14,Xingbo Shi, Zhongqiu Xie, Yuehong Song, Yongjun Tan, Edward S. Yeung, Hongwei Gai*, Super-Localization Spectral Imaging Microscopy of Multi-color Quantum Dot Complex, Analytical Chemistry , 2012, 84(3),1504-1509.

13,Linfen Yu, Qun Li, Hongwei Gai*, Zhanhui Wang*, Chemiluminescence Response of Murine Macrophages on Multilayer Microfluidic Chips, Appl. Biochem. Biotechnol., 2012, 166, 786-795.

12,Hongwei Gai*, Yongjun Li*, Edward S Yeung, Optical detection system of microfluidic chip, Topics in Current Chemistry,2011304:171-201

11,Xingbo Shi, Xianxin Meng, Lichun Sun, Jinhua Liu, Jing Zheng, Hongwei Gai*, Ronghua Yang, Edward S Yeung, Observing photophysical properties of quantum dots in air at the single molecule level: advantages in microarray applications, Lab on a Chip, 2010, 10, 2844-2847. (Outside front cover)

10,Xiaobing Bu, Huaping Chen, Hongwei Gai*, Ronghuang Yang, Edward S Yeung, Scattering imaging of single quantum dots with dark-field microscopy, Analytical Chemistry, 2009, 81, 7507-7509.

9,  Nan Li, Hui Tang, Hongwei Gai,* Xiuling Dong, Qi Wang, Edward S Yeung, Determination of protein surface excess on a liquid/solid interface by single-molecule counting, Analytical and Bioanalytical Chemistry, 2009, 394, 1879-1885.

8,Huaping Chen, Hongwei Gai,* Edward S Yeung, Inhibition of Photobleaching and Blue Shift in Quantum Dots, Chemical Communications, 2009, 1676-1678.

7,Rui Han, Yewang Zhang, Xiuling Dong, Hongwei Gai*, Edward Yeung, Spectral imaging of single molecules by transmission grating-based epi-fluorescence microscopy, Analytica Chimica Acta, 2008, 619, 209-214.

6,Qun Li, Rui Han, Xianxin Meng, Hongwei Gai*, Edward Yeung, Tracking single quantum dot and its spectrum in free solution with controllable thermal diffusion suppression, Analytical Biochemistry, 2008, 377 , 176–181

5Hongwei Gai, Isaac Stayton, Xin Liu, Bingcheng Lin, Yinfa Ma, Visualizing chemical interactions in life sciences with wide-field fluorescence microscopy towards the single-molecule level, Trends in Analytical Chemistry, 2007, 26, 980-992.

4, Hongwei Gai, Gary A. Griess, Borries Demeler, Susan T. Weintraub, Philip Serwer, Routine fluorescence microscopy of single untethered protein molecules confined to a planar zone, Journal of Microscopy, 2007, 226, 256–262.

3,Hongwei Gai, Qi Wang, Yinfa Ma, Bingcheng Lin, Correlations between molecular numbers and molecular masses in an evanescent field and their applications in probing molecular interactions. Angewandte Chemie International Edition, 2005, 44, 5107-5110.

2,Hongwei Gai, Ying Li, Zhan-Hua Silber-Li, Yinfa Ma, Bingcheng Lin, Simultaneously measurements of bulk flow and near wall flow velocity in a microchannel at single molecule level, Lab on a Chip, 2005, 5, 443-449.

1,Hongwei Gai, Linfen Yu, Zhongpeng Dai, Yinfa Ma, Bingcheng Lin., Injection by Hydrostatic Pressure Conjunction with Electrokinetic Force on a Microfluidic Chip, Electrophoresis, 2004, 25,1888-1894.

  


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