石枫教授

发布时间:2014-10-16  访问次数:13223

        

  

  

English version

Prof. Dr. Feng Shi

School of Chemistry & Chemical Engineering

Jiangsu Normal University

Xuzhou, 221116, China

E-mail: fshi@jsnu.edu.cn

Tel: +86-15852157608 or +86-13357953662

Major Research Interests

  • Organocatalytic asymmetric cascade or cycloaddition reactions

  • Asymmetric synthesis of chiral heterocycles

  • Asymmetric catalysis and synthesis

Education and Academic career

  • Professor of Jiangsu Normal University, China, 2015-

  • Associate Professor, Jiangsu Normal University, China,2010-2014

  • Visiting Scholar, Nanyang Technological University, Singapore, 2012-2013 (supervisor: Prof. Teck-Peng Loh)

  • Lecturer, Jiangsu Normal University, China, 2007-2010

  • Ph.D.: Soochow University and University of Science and Technology of China, China (2013, supervisor: Prof. Shu-Jiang Tu and Prof. Liu-Zhu Gong)

  • M.S.: Jiangsu Normal University, China (2004)

  • B.S.: Jiangsu Normal University, China (1998)


    Honors AND Awards

  • The 11th Asian Core Program (ACP) Lectureship Award (to Singapore, Taiwan) (2016)

  • OutstandingYouthFunds of Jiangsu Province (2016)

  • Thieme Chemistry Journal Award (2015)

  • Academic Leader Award of Qing Lan Project in Jiangsu Province (2014)

  • The “333 Project” Awardof Jiangsu Province (2013)

  • Natural Science Awardfrom Chinese Ministry of Education (2011)

  • Science and Technology Award from China Petroleum and Chemical Industry Federation (2008)

  • Natural Scientific Academic Paper Awardfrom Xuzhou Government of China (2008 and 2010)


REPRESENTATIVE Publications

2017:

(1) Hong-Hao Zhang, Cong-Shuai Wang, Can Li,Guang-Jian Mei,Yuxue Li,*Feng Shi*, Design and Enantioselective Construction of AxiallyChiral Naphthyl-Indole Skeletons, Angewandte Chemie, International Edition,2017, DOI: 10.1002/anie.201608150.



2016:

(1) Wang, Yue-Ming; Zhang, Hong-Hao; Li, Can; Fan, Tao; Shi, Feng*, Catalytic asymmetric chemoselective 1,3-dipolar cycloadditions of an azomethine ylide with isatin-derivedimines: diastereo- and enantioselective construction of a spiro[imidazolidine-2,3'-oxindole] framework, Chemical Communications, 2016, 52(9), 1804-1807.


(2) Sun, Xiao-Xue; Zhang, Hong-Hao; Li, Guo-Hao; Meng, Li; Shi, Feng*, Diastereo- and enantioselective construction of an indole-based 2,3-dihydrobenzofuran scaffold via catalyticasymmetric [3+2] cyclizations of quinone monoimides with 3-vinylindoles, Chemical Communications, 2016, 52(14), 2968-2971.


(3) Zhao, Jia-Jia; Tang, Man; Zhang, Hong-Hao; Xu, Meng-Meng; Shi, Feng*, Bronsted acid-catalyzed chemodivergent reactions of ortho-mercaptobenzyl alcohols with 3-alkyl-2-vinylindoles and styrenes: [5+2] cyclization versus hydroxysulfenylation, Chemical Communications, 2016, 52(35), 5953-5956.


(4) Sun, Xiao-Xue; Zhang, Hong-Hao; Li, Guo-Hao; He, Ying-Ying; Shi, Feng*, Catalytic Enantioselective and Regioselective [3+3] Cycloadditions Using 2-Indolylmethanols as 3 C BuildingBlocks, Chemistry - A European Journal, 2016, 22(49), 17526-17532.


(5) Zhang, Hong-Hao; Zhu, Zi-Qi; Fan, Tao; Liang, Jing; Shi, Feng*, Intermediate-Dependent Unusual [4+3], [3+2] and Cascade Reactions of 3-Indolylmethanols: ControllableChemodivergent and Stereoselective Synthesis of Diverse Indole Derivatives, Advanced Synthesis & Catalysis, 2016, 358(8), 1259-1288.


(6) Zhu, Zi-Qi; Shen, Yang; Sun, Xiao-Xue; Tao, Ji-Yu; Liu, Jin-Xi; Shi, Feng*, Catalytic Asymmetric [3+2] Cycloadditions of C-3 Unsubstituted 2-Indolylmethanols: Regio-, Diastereo- andEnantioselective Construction of the Cyclopenta[b]indole Framework, Advanced Synthesis & Catalysis, 2016, 358(23), 3797-3808.


(7) Zhou, Lu-Jia; Zhang, Yu-Chen; Jiang, Fei; He, Guofeng; Yan, Jingjing; Lu, Han*; Zhang, Shu*; Shi, Feng*, Enantioselective Construction of Cyclic Enaminone-Based 3-Substituted 3-Amino-2-oxindole Scaffolds viaCatalytic Asymmetric Additions of Isatin-Derived Imines, Advanced Synthesis & Catalysis, 2016, 358(19), 3069-3083.


(8) Fan, Tao; Zhang, Hong-Hao; Li, Can; Shen, Yang; Shi, Feng*, The Application of N-Protected 3-Vinylindoles in Chiral Phosphoric Acid-Catalyzed [3+2] Cyclization with 3-Indolylmethanols: Monoactivation of the Catalyst to Vinyliminium, Advanced Synthesis & Catalysis, 2016, 358(12), 2017-2031.


(9) Yin, Lei; Wang, Yang; Sun, Meng; Shi, Feng*, Bronsted Acid-Catalyzed [3+2] Cyclodimerization of 3-Alkyl- 2-vinylindoles Leading to the DiastereoselectiveConstruction of a Pyrroloindole Framework, Advanced Synthesis & Catalysis, 2016, 358(7), 1093-1102.


(10) Wu, Jia-Le; Du, Bai-Xiang; Zhang, Yu-Chen; He, Ying-Ying; Wang, Jing-Yi; Wu, Ping; Shi, Feng*, Diastereo- and Enantioselective Construction of Dihydroisocoumarin-Based Spirooxindole Frameworks viaOrganocatalytic Tandem Reactions, Advanced Synthesis & Catalysis, 2016, 358(17), 2777-2790.



(11) Zhang, Yu-Chen; Zhu, Qiu-Ning; Yang, Xue; Zhou, Lu-Jia; Shi, Feng*, Merging Chiral Bronsted Acid/Base Catalysis: An Enantioselective [4 + 2] Cycloaddition of o-Hydroxystyrenes with Azlactones, Journal of Organic Chemistry, 2016, 81(4), 1681-1688.


(12) Wang, Cong-Shuai; Fan, Tao; Zhang, Hong-Hao; Li, Can; Shen, Yang; Mei, Guang-Jian*; Shi, Feng*, Gallium Bromide-Promoted Dearomative Indole Insertion in 3-Indolylmethanols: Chemoselective and (Z/E)-Selective Synthesis of 3,3'-Bisindole Derivatives, Journal of Organic Chemistry, 2016, 81(23), 11734-11742.


(13) Zhu, Qiu-Ning; Zhang, Yu-Chen; Xu, Meng-Meng; Sun, Xiao-Xue; Yang, Xue; Shi, Feng*, Enantioselective Construction of Tetrahydroquinolin-5-one-Based Spirooxindole Scaffold via anOrganocatalytic Asymmetric Multicomponent [3 + 3] Cyclization, Journal of Organic Chemistry, 2016, 81(17), 7898-7907.


(14) Yang, Xue; Zhang, Yu-Chen; Zhu, Qiu-Ning; Tu, Man-Su*; Shi, Feng*, Diastereo- and Enantioselective Construction of the Hexahydrocoumarin Scaffold via an OrganocatalyticAsymmetric [3 + 3] Cyclization, Journal of Organic Chemistry, 2016, 81(12), 5056-5065.


(15) Dai, Wei; Jiang, Xiao-Li; Tao, Ji-Yu; Shi, Feng*, Application of 3-Methyl-2-vinylindoles in Catalytic Asymmetric Povarov Reaction: Diastereo- andEnantioselective Synthesis of Indole-Derived Tetrahydroquinolines, Journal of Organic Chemistry, 2016, 81(1), 185-192.

2015:

(1) Zhao, Jia-Jia; Sun, Si-Bing; He, Sai-Huan; Wu, Qiong; Shi, Feng*, Catalytic Asymmetric Inverse-Electron-Demand Oxa-Diels-Alder Reaction of In Situ Generated ortho-QuinoneMethides with 3-Methyl-2-Vinylindoles, Angewandte Chemie, International Edition,2015,54(18), 5460-5464.


(2)Cong-Shuai Wang, Ren-Yi Zhu, Yu-Chen Zhang and Feng Shi*, Catalytic Chemoselective [3+3] Cycloadditions of Azomethine Ylides with Quinone Monoimides Leading to the Construction of A Dihydrobenzoxazine Scaffold, Chemical Communications,2015, 51, 11798-11801.


(3)Jia-Jia ZhaoYu-Chen ZhangMeng-Meng XuMan Tang, and Feng Shi*, Catalytic Chemo-, E/Z-, and Enantioselective Cyclizations of o-Hydroxybenzyl Alcohols with Dimedone-Derived Enaminones, Journal of Organic Chemistry,2015, 80, 10016−10024.

(4)Wei Dai,Xiao-Li Jiang,Qiong Wu,Feng Shi*, Shu-Jiang Tu,Diastereo- and Enantioselective Construction of 3,3’-Pyrrolidinyldispirooxindole Framework via Catalytic Asymmetric 1,3-Dipolar Cycloadditions, Journal of Organic Chemistry,2015, 80, 5737-5744.


(5)Wang, Yang; Tu, Man-Su; Yin, Lei; Sun, Meng; Shi, Feng*, Bronsted Acid Catalyzed Asymmetric Diels-Alder Reactions: Stereoselective Construction ofSpiro[tetrahydrocarbazole-3,3'-oxindole] Framework, Journal of Organic Chemistry,2015, 80(6), 3223-3232.


(6)Li, Xin; Tan, Wei; Gong, Yu-Xin; Shi, Feng*, Catalyst-Controlled Chemoselective Reaction of 3-Indolylmethanols with Cyclic Enaminones Leading to C2-Functionalized Indoles, Journal of Organic Chemistry,2015, 80(3), 1841-1848.


(7)Wang, Cong-Shuai; Zhu, Ren-Yi; Zheng, Jian; Shi, Feng*; Tu, Shu-Jiang, Enantioselective Construction of Spiro[indoline-3,2'-pyrrole] Framework via Catalytic Asymmetric 1,3-DipolarCycloadditions Using Allenes as Equivalents of Alkynes, Journal of Organic Chemistry,2015, 80(1), 512-520.


(8)Shi, Feng*; Zhang, Hong-Hao; Sun, Xiao-Xue; Liang, Jing; Fan, Tao; Tu, Shu-Jiang, Organocatalytic Asymmetric Cascade Reactions of 7-Vinylindoles: Diastereo- and Enantioselective Synthesis of C7-Functionalized Indoles, Chemistry - A European Journal,2015, 21(8), 3465-3471.


(9)Jiang, Fei; Zhang, Yu-Chen; Sun, Si-Bing; Zhou, Lu-Jia; Shi, Feng*, Organocatalytic Reactions of Indoles with Quinone Imine Ketals: An Alternative Metal-Free Approach to Bioactivemeta-Indolylanilines, Advanced Synthesis & Catalysis,2015,357, 1283-1292.

(10)Yang Wang, Meng Sun, Lei Yin and Feng Shi*, Catalytic Enantioselective Arylative Dearomatization of 3-Methyl-2-vinylindoles Enabled by Reactivity Switch, Advanced Synthesis & Catalysis,2015,357,4031-4040.


(11)Sun, Xiao-Xue; Du, Bai-Xiang; Zhang, Hong-Hao; Ji, Lei; Shi, Feng*, Catalytic Asymmetric Arylation of 3-Indolylmethanols: Enantioselective Synthesis of 3,3'-Bis(indolyl)oxindoles withHigh Atom Economy, ChemCatChem,2015, 7(7), 1211-1221.



2014:

(1)Zhang, Yu-Chen; Zhao, Jia-Jia; Jiang, Fei; Sun, Si-Bing; Shi, Feng*, Organocatalytic Asymmetric Arylative Dearomatization of 2,3-Disubstituted Indoles Enabled by Tandem Reactions, Angewandte Chemie, International Edition,2014, 53(50), 13912-13915.


(2)Tan, Wei; Li, Xin; Gong, Yu-Xin; Ge, Meng-Di; Shi, Feng*, Highly diastereo- and enantioselective construction of a spiro[cyclopenta[b]indole-1,3'-oxindole] scaffold via catalyticasymmetric formal [3+2] cycloadditions, Chemical Communications,2014, 50(100), 15901-15904.


(3)Liu, Yan; Zhang, Hong-Hao; Zhang, Yu-Chen; Jiang, Yan; Shi, Feng*; Tu, Shu-Jiang, Organocatalytic enantioselective and (Z)-selective allylation of 3-indolylmethanol via hydrogen-bond activation, Chemical Communications,2014, 50(81), 12054-12057.


(4)Wang, Yang; Shi, Feng*; Yao, Xi-Xi; Sun, Meng; Dong, Liang; Tu, Shu-Jiang, Catalytic Asymmetric Construction of 3,3'-Spirooxindoles Fused with Seven-Membered Rings by EnantioselectiveTandem Reactions, Chemistry - A European Journal,2014, 20(46), 15047-15052.


(5)Shi, Feng*; Zhu, Ren-Yi; Dai, Wei; Wang, Cong-Shuai; Tu, Shu-Jiang*, Catalytic Asymmetric Formal [3+3] Cycloaddition of an Azomethine Ylide with 3-Indolylmethanol: Enantioselective Construction of a Six-Membered Piperidine Framework,Chemistry - A European Journal,2014, 20(9), 2597-2604.


(6)Dai, Wei; Lu, Han; Li, Xin; Shi, Feng*; Tu, Shu-Jiang, Diastereo- and enantioselective construction of a bispirooxindole scaffold containing a tetrahydro-b-carboline moietythrough an organocatalytic asymmetric cascade reaction, Chemistry - A European Journal,2014, 20(36), 11382-11389.


(7)Wang, Yang; Tu, Man-Su; Shi, Feng*; Tu, Shu-Jiang, Enantioselective construction of the biologically significant dibenzo[1,4]diazepine scaffold via organocatalyticasymmetric three-component reactions, Advanced Synthesis & Catalysis,2014, 356(9), 2009-2019.


(8)Zhou, Lu-Jia; Zhang, Yu-Chen; Zhao, Jia-Jia; Shi, Feng*; Tu, Shu-Jiang, Organocatalytic Arylation of 3-Indolylmethanols via Chemo- and Regiospecific C6-Functionalization of Indoles, Journal of Organic Chemistry,2014, 79(21), 10390-10398.


(9) Zhu, Ren-Yi; Wang, Cong-Shuai; Zheng, Jian; Shi, Feng*; Tu, Shu-Jiang, Organocatalytic Asymmetric Inverse-Electron-Demand 1,3-Dipolar Cycloaddition of N,N'-Cyclic Azomethine Imines, Journal of Organic Chemistry,2014, 79(19), 9305-9312.


(10)Zhang, Hong-Hao; Wang, Yue-Ming; Xie, Yuan-Wei; Zhu, Zi-Qi; Shi, Feng*; Tu, Shu-Jiang, Organocatalytic Chemo-, (E/Z)- and Enantioselective Formal Alkenylation of Indole-Derived Hydroxylactams Using o-Hydroxystyrenes as a Source of Alkenyl Group, Journal of Organic Chemistry,2014, 79(15), 7141-7151.


(11)Zhang, Yu-Chen; Jiang, Fei; Wang, Shu-Liang*; Shi, Feng*; Tu, Shu-Jiang, Organocatalytic Chemo- and Regioselective Oxyarylation of Styrenes via a Cascade Reaction: Remote Activation ofHydroxyl Groups, Journal of Organic Chemistry,2014, 79(13), 6143-6152.


(12)Tan, Wei; Du, Bai-Xiang; Li, Xin; Zhu, Xu; Shi, Feng*; Tu, Shu-Jiang, Catalytic Asymmetric Aza-ene Reaction of 3-Indolylmethanols with Cyclic Enaminones: Enantioselective Approach toC3-Functionalized Indoles, Journal of Organic Chemistry,2014, 79(10), 4635-4643.



2013:

(1)Shi, Feng*; Xing, Gui-Juan; Zhu, Ren-Yi; Tan, Wei; Tu, Shujiang*, A Catalytic Asymmetric Isatin-Involved Povarov Reaction: Diastereo- and Enantioselective Construction of Spiro[indolin-3,2'-quinoline] Scaffold, Organic Letters,2013, 15(1), 128-131.


(2)Shi, Feng*; Tan, Wei; Zhang, Hong-Hao; Li, Mei; Ye, Qin; Ma, Guan-Hua; Tu, Shu-Jiang*; Li, Guigen, Asymmetric Organocatalytic Tandem Cyclization/Transfer Hydrogenation: A Synthetic Strategy for Enantioenriched Nitrogen Heterocycles, Advanced Synthesis & Catalysis,2013, 355(18), 3715-3726.


(3) Shi, Feng*; Zhu, Ren-Yi; Liang, Xia; Tu, Shu-Jiang*, Catalytic Asymmetric 1,3-Dipolar Cycloadditions of Alkynes with Isatin-Derived Azomethine Ylides: Enantioselective Synthesis of Spiro[indoline-3,2'-pyrrole] Derivatives, Advanced Synthesis & Catalysis,2013, 355(11-12), 2447-2458.

(4) Shi, Feng*;Tan, Wei; Zhu, Ren-Yi; Xing, Gui-Juan; Tu, Shu-Jiang*, Catalytic Asymmetric Five-Component Tandem Reaction: Diastereoselective and Enantioselective Synthesis of Densely Functionalized Tetrahydropyridines with Biological Importance, AdvancedSynthesis&Catalysis,2013,355(8),1605-1622.



Chinese version

名:石枫

出生年月:1976年11月10日

学位学历:博士研究生

职称:教授

江苏省杰出青年基金获得者

江苏省“333高层次人才培养工程”第三层次培养对象

江苏省高校“青蓝工程”中青年学术带头人

化学专业硕士生导师

学科专业:有机化学

联系方式:13357953662 或15852157608

E-mail:fshi@jsnu.edu.cn

个人简历

19949- 19986: 徐州师范大学化学教育专业获学士学位

20019- 20046: 徐州师范大学有机化学专业获硕士学位

20047- 20108: 徐州师范大学化学化工学院任教,破格晋升为副教授

20109- 20136: 苏州大学与中科大联合培养化学生物学专业,获博士学位

20128- 20132: 新加坡南洋理工大学访问学者

20158: 破格晋升为江苏师范大学教授

【研究领域和兴趣】

1.有机小分子催化的不对称串联反应与环加成反应

2. 手性杂环骨架的催化不对称构建

3. 不对称催化与合成

【成绩及获奖情况】

近年来一直从事有机小分子催化的不对称多组分反应、串联反应和环加成反应来构建手性杂环骨架的工作,先后主持国家自然科学基金青年项目和面上项目、国家自然科学基金重点项目子课题、江苏省杰出青年基金等。在催化不对称构建手性杂环骨架研究领域取得了丰硕的成果,目前Angew. Chem. Int. Ed.(SCI 一区)Chem. Commun.(SCI 二区TOP)Org. Lett.(SCI 二区TOP)Chem. Eur. J.(SCI 二区)Adv. Synth. Catal.(SCI 二区)J. Org. Chem.(SCI 二区TOP)国际权威刊物上以通讯作者或第一作者发表论文70余,申请发明专利4项

主要学术获奖如下:

1.2016年10月,第十一届亚洲核心计划报告奖(The 11th Asian Core Program (ACP) Lectureship Award),国际学术奖,独立。

2.2014年12月,Thieme Chemistry Journal Award (2015),国际学术奖,独立。

3. 2011年11月,活性杂环骨架的有序构筑教育部科技进步二等奖,排名第三。

4.2010年10月,徐州市优秀自然科学学术论文三等奖,排名第一。

5.2008年11月,徐州市优秀自然科学学术论文二等奖,排名第一。

6.2008年10月,微波促进的芳香化合物的定向转化和杂环骨架的定向构筑,中国石油和化工协会科技进步奖二等奖,排名第二。

【承担的主要科研项目】

序号

项目名称

项目级别

项目来源

项目号

经费

项目排序

起止日期

1

含有吲哚母核的手性杂环骨架的催化不对称构建

江苏省杰出青年基金

江苏省科技厅

BK20160003

100万

排名第一,主持人

2016.7-2019.6

2

催化不对称多组分反应的设计和复杂杂环骨架的对映选择性构建

国家自然科学基金面上项目

国家自然科学基金委

21372002

80万

排名第一,主持人

2014.1-2017.12

3

生物活性分子导向的手性氮杂环骨架的立体选择性合成

国家自然科学基金重点项目

国家自然科学基金委

21232007

300万

排名第三,子课题主持人(经费60万)

2013.1-2017.12

4

基于α-硫氰基芳基乙酮的新型多组分反应的设计和新的杂环骨架的有序构筑

国家自然科学基金青年项目

国家自然科学基金委

21002083

19万

排名第一,主持人

2011.1-2013.12


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