教师风采

韩京

发布者:李甜甜发布时间:2015-04-09浏览次数:4951

  

  

基本信息

学位与职称:博士,副教授(硕士生导师)

专业:药学

研究方向:新药分子的设计与合成多肽药物研发、新药筛选、药用新材料

电子信箱:hj1986424@jsnu.edu.cn

教育经历

2004.09-2008.06 中国药科大学 药学院 制药工程专业 学士

2008.09-2013.06 中国药科大学 药学院 药物化学专业 博士(硕博连读)


工作经历

2018.07至今     江苏师范大学副教授

2017.10-2018.10  University of Copenhagen(丹麦)访问学者

2014.02至今     江苏师范大学任教

2013.07-2014.01  连云港市食品药品监督管理局 主管药师


研究领域与兴趣

近年来主要从事新药分子的设计与合成,多肽类药物的设计、合成及活性研究,以及抗糖尿病及肥胖领域的新药筛选,此外在药用新材料方向也开展了部分工作。近几年在药学领域顶尖期刊J. Med. Chem., Euro. J. Med. Chem., Brit. J. Pharmacol., Biochem. Pharmacol.等发表SCI论文20余篇,其中以第一作者及通讯作者身份发表论文15篇,授权发明专利2项。


主持的主要科研项目

1. 具有降糖和减肥双重作用的新型多肽的设计、合成及生物活性研究,国家自然科学基金,编号:81602964,批准经费:23万,2017.01-2019.12,项目负责人

2. 新型降糖多肽及其纳米缓释制剂的设计、合成生物活性研究,江苏省自然科学基金,编号:BK20150243,批准经费:20万,2015.07-2018.06,项目负责人

3. 长效化胰高血糖素样肽-1衍生物的合成及生物活性研究,江苏省教育厅,编号:14KJB350003,批准经费:5万,2014.08-2016.12,项目负责人

4. 长效化胰高血糖素样肽-1衍生物的合成及生物活性研究,江苏师范大学,编号:14XLR001,批准经费:20万,2015.01-2017.01,项目负责人

5. 新型降糖多肽GLP-1类似物的设计、合成及生物活性研究,江苏省新药与临床药学重点实验室,批准经费:5万,2015.01-2016.12,项目负责人


指导学生情况

1. 20185月,指导陈心雨、周凤、费颖颖三位同学获得“科研创新单项奖学金”

2. 20185月,指导2015级制药班(1531)获得“江苏省省级先进班集体”

3. 20183月,指导陈心雨、周凤、费颖颖三位同学获得“海菲曼科技创新奖学金”

4. 20176月,指导张立倩同学获得“优秀本科毕业论文”

5. 20166月,指导何园欣同学获得“优秀本科毕业论文”


发表的代表性论文

2018年

1. Jing Han*, Yingying Fei, Feng Zhou, Xinyu Chen, Ying Zhang, Lin Liu, Junjie Fu*. Xenopus GLP-1 derived and PEGylated GLP-1 receptor agonists: long-acting hypoglycemic and insulinotropic activities with potential therapeutic utilities. British Journal of Pharmacology, 2018, 175, 544-557.

2. Jing Han*, Yue Huang, Xinyu Chen, Feng Zhou, Yingying Fei, Junjie Fu. Rational design of dimeric lipidated Xenopus glucagon-like peptide 1analogues as long-acting antihyperglycaemic agents. European Journal of Medicinal Chemistry, 2018, 157, 177-187.

3. Jing Han*, Xinyu Chen, Liming Zhao, Junjie Fu*, Lidan Sun*, Ying Zhang, Feng Zhou,Yingying Fei. Lithocholic acid-based peptide delivery system for an enhanced pharmacological and pharmacokinetic profile of Xenopus GLP-1 analogs. Molecular Pharmaceutics, 2018, 15, 2840-2856.

4. Jing Han*, Feng Zhou, Yingying Fei, Xinyu Chen, Junjie Fu*, Hai Qian*. Preparation and pharmaceutical characterizations of lipidated dimeric Xenopusglucagon-like peptide-1 conjugates. Bioconjugate Chemistry, 2018, 29, 390-402.

5. Jing Han*, Yue Huang, Xinyu Chen, Feng Zhou, Yingying Fei, Junjie Fu. Lipidation and conformational constraining for prolonging the effects ofpeptides: Xenopus glucagon-like peptide 1 analogues with potent and long-actinghypoglycemic activity. European Journal of Pharmaceutical Sciences, 2018, 123, 111-123.

6. Jing Han*, Junjie Fu, Lidan Sun, Yue Han, Qiuyi Mao, Fang Liao, Xinshi Zheng, Ke Zhu. Synthesis and pharmaceutical characterization of site specific mycophenolic acid-modified Xenopus glucagon-like peptide-1 analogs. MedChemComm, 2018, 9, 67-80.

2017年

7. Jing Han*, Yiyun Wang, Qinghua Meng, Guangchao Li, Fangmin Huang, Su Wu, Yingying Fei, Feng Zhou, Junjie Fu*. Design, synthesis and biological evaluation of PEGylated Xenopus glucagon-like peptide-1 derivatives as long-acting hypoglycemic agents. European Journal of Medicinal Chemistry, 2017, 132, 81-89.

8. Jing Han*, Yingying Fei, Feng Zhou, Xinyu Chen, Weiwei Zheng, Junjie Fu*. Micellar nanomedicine of novel fatty acid modified Xenopusglucagon-like peptide-1: improved physicochemical characteristics and therapeutic utilities for type 2 diabetes. Molecular Pharmaceutics, 2017, 14, 3954-3967.

9. Jing Han*, Xinyu Chen, Yiyun Wang, Yingying Fei, Feng Zhou, Ying Zhang, Lin Liu, Pengbin Si, Junjie Fu*. Xenopus GLP-1-inspired discovery of novel GLP-1 receptor agonists as long-acting hypoglycemic and insulinotropic agents with significant therapeutic potential. Biochemical Pharmacology, 2017, 142, 155-167.

10. Zheng Li*, Xue Xu, Gang Li, Xiaoting Fu, Yanzhi Liu, Yufeng Feng, Mingyan Wang,Yunting Ouyang, Jing Han*. Improving metabolic stability with deuterium: The discovery ofGPU-028, a potent free fatty acid receptor 4 agonists. Bioorganic & Medicinal Chemistry, 2017, 25, 6647-6652.

2013-2016年

11. Xu Cui, Qinghua Meng, Yingying Chu, Xiaoke Gu, Yan Tang, Feng Zhou, Yingying Fei, Junjie Fu*, Jing Han*. Glucagon-like peptide-1 loaded phospholipid micelles for the treatment of type 2 diabetes: improved pharmacokinetic behaviours and prolonged glucose-lowering effects. RSC Advances, 2016, 6, 94408.

12. Jing Han, Lidan Sun, Xun Huang, Zheng Li, Chenyu Zhang, Hai Qian*, Wenlong Huang*. Novel coumarin modified GLP-1 derivatives with enhanced plasma stability and prolonged in vivo glucose-lowering ability. British Journal of Pharmacology, 2014, 171, 5252-5264.

13. Jing Han, Lidan Sun, Yingying Chu, Zheng Li, Dandan Huang, Xiaoyun Zhu, Hai Qian*, Wenlong Huang*. Design, Synthesis, and Biological Activity of Novel Dicoumarol Glucagon-like Peptide-1 Conjugates. Journal of Medicinal Chemistry, 2013, 56, 9955-9968.

14. Jing Han, Xun Huang, Lidan Sun, Zheng Li, Hai Qian*, Wenlong Huang*. Novel Fatty Chain-modified Glucagon-Like Peptide-1 Conjugates with Enhanced Stability and Prolonged in vivo Activity. Biochemical Pharmacology, 2013, 86, 297-308.

15. JingHan, Lidan Sun, Hai Qian, Wenlong Huang*. Biological activity studies of the novel glucagon-like peptide-1 derivative HJ07. Chinese Journal of Natural Medicines, 2014, 12, 0613-0618.

16. Lidan Sun, Xun Huang, Jing Han, Xingguang Cai, Yuxuan Dai, Yingying Chu,Chuandong Wang, Wenlong Huang*, Hai Qian*. Biochemical Pharmacology, 2016, 110, 80-91.

17. Lidan Sun, ChuandongWang, YuxuanDai, YingyingChu, JingHan, JieZhou,Xingguang Cai, WenlongHuang*, HaiQian*. EuropeanJournalofPharmacology, 2015,767, 211-219.

2011-2012年

18. Xin Deng, Xinxin Zhao, Jing Han, Jingjie Wen, Wenlong Huang*, Hai Qian*, Liang Guang, Synthesis and Biological Evaluation of Berberine Derivatives as IBS Modulator. Lett. Drug Des. Discov., 2012, 9, 489-493.

19. Xiaoyun Zhu, Dandan Huang, Xiaobu Lan, Chunlei Tang, Yan Zhao, Jing Han, Wenlong Huang*, Hai Qian*,The first pharmacophore model for potent G protein-coupled receptor 119 agonist.European Journal of Medicinal Chemistry, 2011, 46,2901-2907.

20. Wei Chen, Yinghong Zhou, Huibin Zhang, Hai Qian*, Wenlong Huang*, BaoweiYang, Jing Han, Jingpei Zhou, Yushi Chi, Shuaijian Ni. Stability and bioactivitystudies on dipeptidyl peptidase IV resistant glucogan-like peptide-1 analogues.Protein and Peptide Letters, 2012,19, 203-211.

21. Wei Chen, Baowei Yang, Huimin Zhou, Lidan Sun, Jie Dou, Hai Qian*, WenlongHuang*, Yicheng Mei, Jing Han. Synthesis, structure-activity relationship of snakecathelicidin BF-15 C-terminal amidated analogs. Peptides, 2011, 32, 2497-2503.

22. Huang Dandan, ZhuXiaoyun, TangChunlei, Mei Yicheng, ChenWei, Yang Baowei,Han Jing, Qian Hai, Huang Wenlong.3D QSAR Pharmacophore Modeling for c-Met Kinase Inhibitors. Medicinal Chemistry, 2012,8, 1117-1125.